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Term Information

Accession
GO:1990306
Name
RSP5-BUL ubiquitin ligase complex
Ontology
cellular_component
Synonyms
RSP5-BUL1 complex, RSP5-BUL2 complex
Alternate IDs
None
Definition
A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation. Source: PMID:9931424, GOC:bhm
Comment
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424
History
See term history for GO:1990306 at QuickGO
Subset
None
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Graph of GO:1990306

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Parents of RSP5-BUL ubiquitin ligase complex (GO:1990306)
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RSP5-BUL ubiquitin ligase complex [is_a relation] is_a  transferase complex (GO:1990234)
RSP5-BUL ubiquitin ligase complex [BFO:0000050 relation] BFO:0000050  intracellular anatomical structure (GO:0005622)

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