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Term Information

Accession
GO:1990304
Name
MUB1-RAD6-UBR2 ubiquitin ligase complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. Source: PMID:18070918, GOC:bhm
Comment
This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.
History
See term history for GO:1990304 at QuickGO
Subset
None
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Graph of GO:1990304

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Parents of MUB1-RAD6-UBR2 ubiquitin ligase complex (GO:1990304)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MUB1-RAD6-UBR2 ubiquitin ligase complex [BFO:0000050 relation] BFO:0000050  intracellular anatomical structure (GO:0005622)
MUB1-RAD6-UBR2 ubiquitin ligase complex [is_a relation] is_a  transferase complex (GO:1990234)

This term has no children.

IntAct
EBI-9117531