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Term Information

Accession
GO:1990303
Name
UBR1-RAD6 ubiquitin ligase complex
Ontology
cellular_component
Synonyms
UBR1-RAD6 complex
Alternate IDs
None
Definition
A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. Source: PMID:19531475, GOC:bhm
Comment
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
History
See term history for GO:1990303 at QuickGO
Subset
None
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Graph of GO:1990303

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Parents of UBR1-RAD6 ubiquitin ligase complex (GO:1990303)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
UBR1-RAD6 ubiquitin ligase complex [BFO:0000050 relation] BFO:0000050  intracellular anatomical structure (GO:0005622)
UBR1-RAD6 ubiquitin ligase complex [is_a relation] is_a  transferase complex (GO:1990234)

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IntAct
EBI-9103673