Planteome: Term Details for "platelet-derived growth factor complex" (GO:1990265)

Accession: GO:1990265
Name: platelet-derived growth factor complex
Ontology: cellular_component
Synonyms: PDGF complex, PDGF-AA dimer, PDGF-AB dimer, PDGF-BB dimer, PDGF-CC dimer, PDGF-DD dimer
Alternate IDs: None
Definition: A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). Source: PMID:11331882, GOC:bhm
Comment: An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay).
History: See term history for GO:1990265 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to platelet-derived growth factor complex.; Link to all direct and indirect annotations to platelet-derived growth factor complex.; Link to all direct and indirect annotations download (limited to first 10,000) for platelet-derived growth factor complex.
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