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Term Information

Accession
GO:1990000
Name
amyloid fibril formation
Ontology
biological_process
Synonyms
amyloid fibril assembly, amyloid structure assembly, amyloid structure formation
Alternate IDs
None
Definition
The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. Source: GOC:jj, GOC:ppm, GOC:cvs, PMID:28937655, PMID:21148556, GOC:sj, PMID:22817896, PMID:29654159
Comment
Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
History
See term history for GO:1990000 at QuickGO
Subset
None
Feedback
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Graph of GO:1990000

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Parents of amyloid fibril formation (GO:1990000)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
amyloid fibril formation [is_a relation] is_a  supramolecular fiber organization (GO:0097435)
amyloid fibril formation [is_a relation] is_a  protein metabolic process (GO:0019538)
Children of amyloid fibril formation (GO:1990000)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of amyloid fibril formation (GO:1905906) [RO:0002211 relation] RO:0002211  amyloid fibril formation
positive regulation of amyloid fibril formation (GO:1905908) [RO:0002213 relation] RO:0002213  amyloid fibril formation
negative regulation of amyloid fibril formation (GO:1905907) [RO:0002212 relation] RO:0002212  amyloid fibril formation
None.