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Term Information

Accession
GO:1905907
Name
negative regulation of amyloid fibril formation
Ontology
biological_process
Synonyms
down regulation of amyloid fibril formation, down-regulation of amyloid fibril formation, downregulation of amyloid fibril formation, down regulation of amyloid fibril assembly, down regulation of amyloid structure assembly, down regulation of amyloid structure formation, down-regulation of amyloid fibril assembly, down-regulation of amyloid structure assembly, down-regulation of amyloid structure formation, downregulation of amyloid fibril assembly, downregulation of amyloid structure assembly, downregulation of amyloid structure formation, inhibition of amyloid fibril assembly, inhibition of amyloid structure assembly, inhibition of amyloid structure formation, negative regulation of amyloid fibril assembly, negative regulation of amyloid structure assembly, negative regulation of amyloid structure formation, inhibition of amyloid fibril formation
Alternate IDs
None
Definition
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation. Source: PMID:23106396, GOC:TermGenie, GOC:bc, GO_REF:0000058, GOC:aruk
Comment
Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
History
See term history for GO:1905907 at QuickGO
Subset
None
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Graph of GO:1905907

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Parents of negative regulation of amyloid fibril formation (GO:1905907)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of amyloid fibril formation [RO:0002212 relation] RO:0002212  amyloid fibril formation (GO:1990000)
negative regulation of amyloid fibril formation [is_a relation] is_a  negative regulation of supramolecular fiber organization (GO:1902904)
negative regulation of amyloid fibril formation [is_a relation] is_a  negative regulation of protein metabolic process (GO:0051248)
negative regulation of amyloid fibril formation [is_a relation] is_a  regulation of amyloid fibril formation (GO:1905906)

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