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Term Information

Accession
GO:0140467
Name
integrated stress response signaling
Ontology
biological_process
Synonyms
ISR
Alternate IDs
None
Definition
The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. Source: PMID:27629041
Comment
None
History
See term history for GO:0140467 at QuickGO
Subset
None
Feedback
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Graph of GO:0140467

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Parents of integrated stress response signaling (GO:0140467)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
integrated stress response signaling [is_a relation] is_a  cellular response to stress (GO:0033554)
Children of integrated stress response signaling (GO:0140467)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
PERK-mediated unfolded protein response (GO:0036499) [is_a relation] is_a  integrated stress response signaling
HRI-mediated signaling (GO:0140468) [is_a relation] is_a  integrated stress response signaling
GCN2-mediated signaling (GO:0140469) [is_a relation] is_a  integrated stress response signaling
PKR-mediated signaling (GO:0039585) [is_a relation] is_a  integrated stress response signaling