Planteome: Term Details for "general transcription initiation factor activity" (GO:0140223)

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Term Information

Accession: GO:0140223
Name: general transcription initiation factor activity
Ontology: molecular_function
Synonyms: GTF activity, basal transcription factor activity, general transcription factor activity
Alternate IDs: None
Definition: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. Source: GOC:txnOH-2018
Comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.
History: See term history for GO:0140223 at QuickGO
Subset: goslim_drosophila; goslim_generic
Related: Link to all annotated objects annotated to general transcription initiation factor activity.; Link to all direct and indirect annotations to general transcription initiation factor activity.; Link to all direct and indirect annotations download (limited to first 10,000) for general transcription initiation factor activity.
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GO:0008150 biological_process
BFO:0000015 process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0006725 cellular aromatic compound metabolic process
GO:0044249 cellular biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0046483 heterocycle metabolic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044238 primary metabolic process
GO:0019438 aromatic compound biosynthetic process
GO:0044271 cellular nitrogen compound biosynthetic process
BFO:0000001 entity
GO:0018130 heterocycle biosynthetic process
GO:0090304 nucleic acid metabolic process
BFO:0000003 occurrent
GO:1901362 organic cyclic compound biosynthetic process
GO:0009059 macromolecule biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0016070 RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0006351 DNA-templated transcription
GO:0003674 molecular_function
GO:0140223 general transcription initiation factor activity
GO:0001181 RNA polymerase I general transcription initiation factor activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0000995 RNA polymerase III general transcription initiation factor activity

Parents of general transcription initiation factor activity (GO:0140223)

subject	relation	object
general transcription initiation factor activity	BFO:0000050	DNA-templated transcription (GO:0006351)
general transcription initiation factor activity	is_a	molecular_function (GO:0003674)

Children of general transcription initiation factor activity (GO:0140223)

subject	relation	object
RNA polymerase I general transcription initiation factor activity (GO:0001181)	is_a	general transcription initiation factor activity
RNA polymerase II general transcription initiation factor activity (GO:0016251)	is_a	general transcription initiation factor activity
RNA polymerase III general transcription initiation factor activity (GO:0000995)	is_a	general transcription initiation factor activity