Planteome: Term Details for "cardiac endothelial to mesenchymal transition" (GO:0140074)

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Term Information

Accession: GO:0140074
Name: cardiac endothelial to mesenchymal transition
Ontology: biological_process
Synonyms: EndMT, EndoMT
Alternate IDs: None
Definition: A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes. Source: PMID:26053665, PMID:16162442, GOC:BHF, GOC:nc
Comment: None
History: See term history for GO:0140074 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to cardiac endothelial to mesenchymal transition.; Link to all direct and indirect annotations to cardiac endothelial to mesenchymal transition.; Link to all direct and indirect annotations download (limited to first 10,000) for cardiac endothelial to mesenchymal transition.
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BFO:0000001 entity
GO:0008150 biological_process
BFO:0000003 occurrent
GO:0048856 anatomical structure development
GO:0032501 multicellular organismal process
BFO:0000015 process
GO:0032502 developmental process
GO:0007275 multicellular organism development
GO:0009987 cellular process
GO:0048731 system development
GO:0048513 animal organ development
GO:0048869 cellular developmental process
GO:0009888 tissue development
GO:0030154 cell differentiation
GO:0060485 mesenchyme development
GO:0048762 mesenchymal cell differentiation
GO:0140074 cardiac endothelial to mesenchymal transition
GO:0062001 negative regulation of cardiac endothelial to mesenchymal transition
GO:0062000 positive regulation of cardiac endothelial to mesenchymal transition
GO:0061999 regulation of cardiac endothelial to mesenchymal transition

Parents of cardiac endothelial to mesenchymal transition (GO:0140074)

subject	relation	object
cardiac endothelial to mesenchymal transition	is_a	mesenchymal cell differentiation (GO:0048762)

Children of cardiac endothelial to mesenchymal transition (GO:0140074)

subject	relation	object
positive regulation of cardiac endothelial to mesenchymal transition (GO:0062000)	RO:0002213	cardiac endothelial to mesenchymal transition
negative regulation of cardiac endothelial to mesenchymal transition (GO:0062001)	RO:0002212	cardiac endothelial to mesenchymal transition
regulation of cardiac endothelial to mesenchymal transition (GO:0061999)	RO:0002211	cardiac endothelial to mesenchymal transition