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Term Information

Accession
GO:0140074
Name
cardiac endothelial to mesenchymal transition
Ontology
biological_process
Synonyms
EndMT, EndoMT
Alternate IDs
None
Definition
A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes. Source: PMID:26053665, PMID:16162442, GOC:BHF, GOC:nc
Comment
None
History
See term history for GO:0140074 at QuickGO
Subset
None
Feedback
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Graph of GO:0140074

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Parents of cardiac endothelial to mesenchymal transition (GO:0140074)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cardiac endothelial to mesenchymal transition [is_a relation] is_a  mesenchymal cell differentiation (GO:0048762)
Children of cardiac endothelial to mesenchymal transition (GO:0140074)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of cardiac endothelial to mesenchymal transition (GO:0062001) [RO:0002212 relation] RO:0002212  cardiac endothelial to mesenchymal transition
positive regulation of cardiac endothelial to mesenchymal transition (GO:0062000) [RO:0002213 relation] RO:0002213  cardiac endothelial to mesenchymal transition
regulation of cardiac endothelial to mesenchymal transition (GO:0061999) [RO:0002211 relation] RO:0002211  cardiac endothelial to mesenchymal transition
None.