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Term Information

Accession
GO:0120113
Name
cytoplasm to vacuole transport by the NVT pathway
Ontology
biological_process
Synonyms
protein localization by the NVT pathway, protein localization by the Nbr1-mediated vacuolar targeting pathway, cytoplasm to vacuole targeting, cytoplasm-to-vacuole targeting
Alternate IDs
None
Definition
A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe. Source: PMID:26365378
Comment
None
History
See term history for GO:0120113 at QuickGO
Subset
None
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Graph of GO:0120113

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Parents of cytoplasm to vacuole transport by the NVT pathway (GO:0120113)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cytoplasm to vacuole transport by the NVT pathway [BFO:0000051 relation] BFO:0000051  vacuolar protein processing (GO:0006624)
cytoplasm to vacuole transport by the NVT pathway [is_a relation] is_a  protein targeting to vacuole (GO:0006623)

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None.