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Term Information

Accession
GO:0101005
Name
ubiquitinyl hydrolase activity
Ontology
molecular_function
Synonyms
deubiquitinase activity, ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
Alternate IDs
GO:1904265
Definition
Catalysis of the hydrolysis of ubiquitin from proteins and other molecules. Source: GOC:mec
Comment
There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
History
See term history for GO:0101005 at QuickGO
Subset
None
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Graph of GO:0101005

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Parents of ubiquitinyl hydrolase activity (GO:0101005)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ubiquitinyl hydrolase activity [is_a relation] is_a  catalytic activity, acting on a protein (GO:0140096)
ubiquitinyl hydrolase activity [is_a relation] is_a  hydrolase activity (GO:0016787)
Children of ubiquitinyl hydrolase activity (GO:0101005)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Lys48-specific deubiquitinase activity (GO:1990380) [is_a relation] is_a  ubiquitinyl hydrolase activity
Lys63-specific deubiquitinase activity (GO:0061578) [is_a relation] is_a  ubiquitinyl hydrolase activity
ubiquitinyl hydrolase activity, acting on linear ubiquitin (GO:0061815) [is_a relation] is_a  ubiquitinyl hydrolase activity
thiol-dependent ubiquitin-specific protease activity (GO:0004843) [is_a relation] is_a  ubiquitinyl hydrolase activity
Reactome
R-HSA-9674127