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Term Information

Accession
GO:0097696
Name
receptor signaling pathway via STAT
Ontology
biological_process
Synonyms
STAT signalling pathway, kinase activated-STAT cascade, kinase-STAT cascade
Alternate IDs
None
Definition
An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. Source: GOC:rjd, PMID:24587195, PMID:21534947
Comment
In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins.
History
See term history for GO:0097696 at QuickGO
Subset
None
Feedback
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Graph of GO:0097696

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Parents of receptor signaling pathway via STAT (GO:0097696)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
receptor signaling pathway via STAT [is_a relation] is_a  cell surface receptor signaling pathway (GO:0007166)
Children of receptor signaling pathway via STAT (GO:0097696)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of receptor signaling pathway via STAT (GO:1904893) [RO:0002212 relation] RO:0002212  receptor signaling pathway via STAT
positive regulation of receptor signaling pathway via STAT (GO:1904894) [RO:0002213 relation] RO:0002213  receptor signaling pathway via STAT
receptor signaling pathway via JAK-STAT (GO:0007259) [is_a relation] is_a  receptor signaling pathway via STAT
regulation of receptor signaling pathway via STAT (GO:1904892) [RO:0002211 relation] RO:0002211  receptor signaling pathway via STAT
None.