Planteome: Term Details for "neurofibrillary tangle" (GO:0097418)

Accession: GO:0097418
Name: neurofibrillary tangle
Ontology: cellular_component
Synonyms: flame-shaped neurofibrillary tangle, star-shaped neurofibrillary tangle
Alternate IDs: None
Definition: Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. Source: NIF_Subcellular:sao2409833926, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:nlx_subcell_20090201
Comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
History: See term history for GO:0097418 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to neurofibrillary tangle.; Link to all direct and indirect annotations to neurofibrillary tangle.; Link to all direct and indirect annotations download (limited to first 10,000) for neurofibrillary tangle.
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subject	relation	object
neurofibrillary tangle	is_a	inclusion body (GO:0016234)

This term has no children.