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Term Information

Accession
GO:0097193
Name
intrinsic apoptotic signaling pathway
Ontology
biological_process
Synonyms
intrinsic apoptotic pathway, intrinsic apoptotic signalling pathway, mitochondrial-mediated apoptotic pathway, induction of apoptosis by intracellular signals, intrinsic apoptosis
Alternate IDs
GO:0008629
Definition
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). Source: PMID:11919192, PMID:18852119, GOC:yaf, GOC:mtg_apoptosis, PMID:17340152
Comment
The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
History
See term history for GO:0097193 at QuickGO
Subset
None
Feedback
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Graph of GO:0097193

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Parents of intrinsic apoptotic signaling pathway (GO:0097193)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
intrinsic apoptotic signaling pathway [is_a relation] is_a  apoptotic signaling pathway (GO:0097190)
intrinsic apoptotic signaling pathway [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of intrinsic apoptotic signaling pathway (GO:0097193)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) [RO:0002212 relation] RO:0002212  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to hypoxia (GO:1990144) [is_a relation] is_a  intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244) [RO:0002213 relation] RO:0002213  intrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway (GO:2001242) [RO:0002211 relation] RO:0002211  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to nitrosative stress (GO:1990442) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to osmotic stress (GO:0008627) [is_a relation] is_a  intrinsic apoptotic signaling pathway
None.