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Term Information

Accession
GO:0097190
Name
apoptotic signaling pathway
Ontology
biological_process
Synonyms
apoptotic signalling pathway, induction of apoptosis by extracellular signals
Alternate IDs
GO:0008624
Definition
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. Source: GOC:mtg_apoptosis
Comment
This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
History
See term history for GO:0097190 at QuickGO
Subset
None
Feedback
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Graph of GO:0097190

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Parents of apoptotic signaling pathway (GO:0097190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apoptotic signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)
apoptotic signaling pathway [BFO:0000050 relation] BFO:0000050  apoptotic process (GO:0006915)
Children of apoptotic signaling pathway (GO:0097190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of apoptotic signaling pathway (GO:2001234) [RO:0002212 relation] RO:0002212  apoptotic signaling pathway
positive regulation of apoptotic signaling pathway (GO:2001235) [RO:0002213 relation] RO:0002213  apoptotic signaling pathway
cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199) [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway
granzyme-mediated apoptotic signaling pathway (GO:0008626) [is_a relation] is_a  apoptotic signaling pathway
regulation of apoptotic signaling pathway (GO:2001233) [RO:0002211 relation] RO:0002211  apoptotic signaling pathway
apoptosome assembly (GO:0097314) [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway
intrinsic apoptotic signaling pathway (GO:0097193) [is_a relation] is_a  apoptotic signaling pathway
extrinsic apoptotic signaling pathway (GO:0097191) [is_a relation] is_a  apoptotic signaling pathway
hormone-mediated apoptotic signaling pathway (GO:0008628) [is_a relation] is_a  apoptotic signaling pathway
release of cytochrome c from mitochondria (GO:0001836) [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway
mitochondrial outer membrane permeabilization (GO:0097345) [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway
None.