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Term Information

Accession
GO:0090625
Name
siRNA-mediated gene silencing by mRNA destabilization
Ontology
biological_process
Synonyms
mRNA cleavage involved in gene silencing by siRNA, mRNA destabilization-mediated gene silencing by siRNA, gene silencing by mRNA cleavage
Alternate IDs
None
Definition
An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA. Source: GOC:BHF_miRNA, GOC:rph, PMID:15260970, GOC:BHF
Comment
None
History
See term history for GO:0090625 at QuickGO
Subset
None
Feedback
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Graph of GO:0090625

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Parents of siRNA-mediated gene silencing by mRNA destabilization (GO:0090625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
siRNA-mediated gene silencing by mRNA destabilization [is_a relation] is_a  siRNA-mediated gene silencing (GO:0140766)
siRNA-mediated gene silencing by mRNA destabilization [is_a relation] is_a  mRNA destabilization (GO:0061157)
Children of siRNA-mediated gene silencing by mRNA destabilization (GO:0090625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
siRNA-mediated long-distance post-transcriptional gene silencing (GO:0010495) [is_a relation] is_a  siRNA-mediated gene silencing by mRNA destabilization
None.