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Term Information

Accession
GO:0086094
Name
positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
Ontology
biological_process
Synonyms
adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation
Alternate IDs
None
Definition
An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction. Source: GOC:BHF, GOC:bf, PMID:21099118, GOC:mtg_cardiac_conduct_nov11
Comment
None
History
See term history for GO:0086094 at QuickGO
Subset
None
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Graph of GO:0086094

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Parents of positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction (GO:0086094)
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positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [is_a relation] is_a  adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate (GO:0140200)
positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [BFO:0000050 relation] BFO:0000050  positive regulation of cardiac muscle contraction (GO:0060452)

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