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Term Information

Accession
GO:0080120
Name
CAAX-box protein maturation
Ontology
biological_process
Synonyms
CAAX-box protein processing, farnesylated protein maturation
Alternate IDs
None
Definition
A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase. Source: PMID:17114793, PMID:18641086, PMID:12039957
Comment
None
History
See term history for GO:0080120 at QuickGO
Subset
None
Feedback
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Graph of GO:0080120

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Parents of CAAX-box protein maturation (GO:0080120)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CAAX-box protein maturation [is_a relation] is_a  protein maturation (GO:0051604)
CAAX-box protein maturation [BFO:0000051 relation] BFO:0000051  protein prenylation (GO:0018342)
CAAX-box protein maturation [BFO:0000051 relation] BFO:0000051  protein processing (GO:0016485)
CAAX-box protein maturation [is_a relation] is_a  cellular protein metabolic process (GO:0044267)
Children of CAAX-box protein maturation (GO:0080120)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CAAX-box protein modification (GO:0071587) [BFO:0000050 relation] BFO:0000050  CAAX-box protein maturation
CAAX-box protein processing (GO:0071586) [BFO:0000050 relation] BFO:0000050  CAAX-box protein maturation
None.