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Term Information

Accession
GO:0072546
Name
EMC complex
Ontology
cellular_component
Synonyms
ER membrane protein complex, endoplasmic reticulum membrane protein complex
Alternate IDs
None
Definition
A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. Source: PMID:30415835, PMID:29242231, PMID:32459176
Comment
Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect.
History
See term history for GO:0072546 at QuickGO
Subset
None
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Graph of GO:0072546

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Parents of EMC complex (GO:0072546)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
EMC complex [BFO:0000050 relation] BFO:0000050  endoplasmic reticulum membrane (GO:0005789)
EMC complex [is_a relation] is_a  endoplasmic reticulum protein-containing complex (GO:0140534)
EMC complex [is_a relation] is_a  membrane protein complex (GO:0098796)

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None.