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Ragulator complex

Term Information

Accession
GO:0071986
Name
Ragulator complex
Ontology
cellular_component
Synonyms
MAPKSP1/ROBLD3/C11orf59 complex, Rag GEF, EGO complex, EGO-GSE complex, GSE complex, GTPase-containing complex for Gap1p sorting in the endosome
Alternate IDs
GO:0034449, GO:0034448
Definition
A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signalling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). Source: PMID:29199950, PMID:16732272, GOC:vw, PMID:15989961, PMID:19748353, PMID:22980980, PMID:19177150, PMID:20381137
Comment
None
History
See term history for GO:0071986 at QuickGO
Subset
None
Feedback
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Graph of GO:0071986

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Parents of Ragulator complex (GO:0071986)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Ragulator complex [BFO:0000050 relation] BFO:0000050  vacuolar membrane (GO:0005774)
Ragulator complex [is_a relation] is_a  membrane protein complex (GO:0098796)
Ragulator complex [is_a relation] is_a  guanyl-nucleotide exchange factor complex (GO:0032045)

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