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Term Information

Accession
GO:0071630
Name
nuclear protein quality control by the ubiquitin-proteasome system
Ontology
biological_process
Synonyms
nucleus-associated proteasomal ubiquitin-dependent protein breakdown, nucleus-associated proteasomal ubiquitin-dependent protein catabolism, nucleus-associated proteasomal ubiquitin-dependent protein degradation, ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation. Source: PMID:21211726, GOC:rb, PMID:21324894, PMID:20080635, GOC:mah
Comment
See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
History
See term history for GO:0071630 at QuickGO
Subset
None
Feedback
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Graph of GO:0071630

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Parents of nuclear protein quality control by the ubiquitin-proteasome system (GO:0071630)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear protein quality control by the ubiquitin-proteasome system [is_a relation] is_a  proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)
nuclear protein quality control by the ubiquitin-proteasome system [BFO:0000050 relation] BFO:0000050  cellular response to misfolded protein (GO:0071218)
nuclear protein quality control by the ubiquitin-proteasome system [is_a relation] is_a  protein quality control for misfolded or incompletely synthesized proteins (GO:0006515)
Children of nuclear protein quality control by the ubiquitin-proteasome system (GO:0071630)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process (GO:1901044) [BFO:0000050 relation] BFO:0000050  nuclear protein quality control by the ubiquitin-proteasome system
None.