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Term Information

Accession
GO:0070816
Name
phosphorylation of RNA polymerase II C-terminal domain
Ontology
biological_process
Synonyms
CTD domain phosphorylation of RNA polymerase II, generation of II(0) form of RNA polymerase II, generation of hyperphosphorylated CTD of RNA polymerase II, hyperphosphorylation of RNA polymerase II C-terminal domain
Alternate IDs
GO:0016245
Definition
The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. Source: GOC:krc, GOC:mah, PMID:17079683
Comment
None
History
See term history for GO:0070816 at QuickGO
Subset
None
Feedback
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Graph of GO:0070816

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Parents of phosphorylation of RNA polymerase II C-terminal domain (GO:0070816)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
phosphorylation of RNA polymerase II C-terminal domain [is_a relation] is_a  protein phosphorylation (GO:0006468)
phosphorylation of RNA polymerase II C-terminal domain [is_a relation] is_a  regulation of transcription by RNA polymerase II (GO:0006357)
Children of phosphorylation of RNA polymerase II C-terminal domain (GO:0070816)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of phosphorylation of RNA polymerase II C-terminal domain (GO:1901408) [RO:0002212 relation] RO:0002212  phosphorylation of RNA polymerase II C-terminal domain
phosphorylation of RNA polymerase II C-terminal domain serine 5 residues (GO:0071620) [is_a relation] is_a  phosphorylation of RNA polymerase II C-terminal domain
phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex (GO:1901921) [is_a relation] is_a  phosphorylation of RNA polymerase II C-terminal domain
regulation of phosphorylation of RNA polymerase II C-terminal domain (GO:1901407) [RO:0002211 relation] RO:0002211  phosphorylation of RNA polymerase II C-terminal domain
phosphorylation of RNA polymerase II C-terminal domain serine 2 residues (GO:0071619) [is_a relation] is_a  phosphorylation of RNA polymerase II C-terminal domain
positive regulation of phosphorylation of RNA polymerase II C-terminal domain (GO:1901409) [RO:0002213 relation] RO:0002213  phosphorylation of RNA polymerase II C-terminal domain
None.