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Term Information

Accession
GO:0070772
Name
PAS complex
Ontology
cellular_component
Synonyms
autophagy-specific phosphatidylinositol 3-kinase complex
Alternate IDs
None
Definition
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p. Source: PMID:19037259, PMID:18950639, PMID:19158662
Comment
None
History
See term history for GO:0070772 at QuickGO
Subset
None
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Graph of GO:0070772

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Parents of PAS complex (GO:0070772)
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PAS complex [is_a relation] is_a  phosphatidylinositol 3-kinase complex, class III (GO:0035032)
PAS complex [BFO:0000050 relation] BFO:0000050  vacuolar membrane (GO:0005774)

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