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Term Information

Accession
GO:0070371
Name
ERK1 and ERK2 cascade
Ontology
biological_process
Synonyms
ERK1 and ERK2 signaling pathway, ERK1 and ERK2 signalling pathway, ERK1/2 cascade, extracellular signal-regulated kinase 1/2 (ERK1/2) cascade, extracellular signal-regulated kinase 1/2 cascade, ERK1 cascade, ERK2 cascade, MAPK1 cascade, MAPK3 cascade, ERK cascade
Alternate IDs
None
Definition
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. Source: GOC:signaling, ISBN:0896039986, PMID:20811974, PMID:28903453, ISBN:0121245462, GOC:add
Comment
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases.
History
See term history for GO:0070371 at QuickGO
Subset
None
Feedback
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Graph of GO:0070371

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Parents of ERK1 and ERK2 cascade (GO:0070371)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERK1 and ERK2 cascade [is_a relation] is_a  MAPK cascade (GO:0000165)
Children of ERK1 and ERK2 cascade (GO:0070371)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of ERK1 and ERK2 cascade (GO:0070373) [RO:0002212 relation] RO:0002212  ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade (GO:0070374) [RO:0002213 relation] RO:0002213  ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade (GO:0070372) [RO:0002211 relation] RO:0002211  ERK1 and ERK2 cascade
None.