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Term Information

Accession
GO:0070266
Name
necroptotic process
Ontology
biological_process
Synonyms
RIPK1-mediated regulated necrosis, PARP-dependent cell death, activation of necroptosis, activation of necroptosis by extracellular signals, activation of necroptosis in response to extracellular signals, activation of necroptosis of activated-T cells, establishment of necroptosis, establishment of necroptosis of activated-T cells, extracellular signal-induced necroptosis, parthanatos, TNF-induced necroptosis, necroptosis, induction of necroptosis, induction of necroptosis by extracellular signals, induction of necroptosis of activated-T cells, programmed necrosis, programmed necrotic cell death
Alternate IDs
GO:0060554, GO:0060555, GO:0060553
Definition
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. Source: GOC:dph, GOC:tb, PMID:20823910, GOC:BHF, PMID:21760595, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:21737330, PMID:21876153
Comment
Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
History
See term history for GO:0070266 at QuickGO
Subset
None
Feedback
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Graph of GO:0070266

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Parents of necroptotic process (GO:0070266)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
necroptotic process [is_a relation] is_a  programmed necrotic cell death (GO:0097300)
Children of necroptotic process (GO:0070266)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ripoptosome assembly involved in necroptotic process (GO:1901026) [BFO:0000050 relation] BFO:0000050  necroptotic process
negative regulation of necroptotic process (GO:0060546) [RO:0002212 relation] RO:0002212  necroptotic process
execution phase of necroptosis (GO:0097528) [BFO:0000050 relation] BFO:0000050  necroptotic process
necroptotic signaling pathway (GO:0097527) [BFO:0000050 relation] BFO:0000050  necroptotic process
positive regulation of necroptotic process (GO:0060545) [RO:0002213 relation] RO:0002213  necroptotic process
regulation of necroptotic process (GO:0060544) [RO:0002211 relation] RO:0002211  necroptotic process
None.