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Term Information

Accession
GO:0070265
Name
necrotic cell death
Ontology
biological_process
Synonyms
cellular necrosis, necrosis
Alternate IDs
None
Definition
A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. Source: PMID:20823910, GOC:mtg_apoptosis, PMID:18846107
Comment
Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
History
See term history for GO:0070265 at QuickGO
Subset
None
Feedback
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Graph of GO:0070265

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Parents of necrotic cell death (GO:0070265)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
necrotic cell death [is_a relation] is_a  cell death (GO:0008219)
Children of necrotic cell death (GO:0070265)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of necrotic cell death (GO:0010940) [RO:0002213 relation] RO:0002213  necrotic cell death
oncosis (GO:0070267) [BFO:0000050 relation] BFO:0000050  necrotic cell death
negative regulation of necrotic cell death (GO:0060547) [RO:0002212 relation] RO:0002212  necrotic cell death
programmed necrotic cell death (GO:0097300) [is_a relation] is_a  necrotic cell death
regulation of necrotic cell death (GO:0010939) [RO:0002211 relation] RO:0002211  necrotic cell death
None.