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Term Information

Accession
GO:0070059
Name
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Ontology
biological_process
Synonyms
ER stress-induced apoptosis, apoptosis in response to ER stress, apoptosis triggered by ER stress, endoplasmic reticulum stress-induced apoptosis, intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress, apoptosis in response to endoplasmic reticulum stress
Alternate IDs
None
Definition
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. Source: PMID:18701708, GOC:mah, GOC:mtg_apoptosis
Comment
None
History
See term history for GO:0070059 at QuickGO
Subset
None
Feedback
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Graph of GO:0070059

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Parents of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [is_a relation] is_a  response to endoplasmic reticulum stress (GO:0034976)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [is_a relation] is_a  intrinsic apoptotic signaling pathway (GO:0097193)
Children of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236) [RO:0002212 relation] RO:0002212  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0036483) [is_a relation] is_a  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235) [RO:0002211 relation] RO:0002211  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902237) [RO:0002213 relation] RO:0002213  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
None.