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Term Information

Accession
GO:0061630
Name
ubiquitin protein ligase activity
Ontology
molecular_function
Synonyms
protein ubiquitination activity, ubiquitin ligase activity, E3, ER-associated E3 ligase, APC-Cdc20 complex activity, APC-fizzy related complex activity, E3 involved in endoplasmic reticulum-associated degradation, ubiquitin ligase activity involved in ER-associated degradation pathway, ubiquitin protein ligase activity involved in ER-associated degradation pathway, ubiquitin protein ligase activity involved in ERAD pathway, ubiquitin protein ligase activity involved in chloroplast disassembly, ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition
Alternate IDs
GO:1904264, GO:0090302, GO:0090622, GO:1904822
Definition
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. Source: GOC:dph, GOC:tb, GOC:BioGRID, GOC:mah, PMID:22863777
Comment
This enzyme catalyzes a transferase reaction.
History
See term history for GO:0061630 at QuickGO
Subset
None
Feedback
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Graph of GO:0061630

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Parents of ubiquitin protein ligase activity (GO:0061630)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ubiquitin protein ligase activity [is_a relation] is_a  ubiquitin-like protein ligase activity (GO:0061659)
ubiquitin protein ligase activity [is_a relation] is_a  ubiquitin-protein transferase activity (GO:0004842)
Children of ubiquitin protein ligase activity (GO:0061630)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of ubiquitin protein ligase activity (GO:1904666) [RO:0002211 relation] RO:0002211  ubiquitin protein ligase activity
positive regulation of ubiquitin protein ligase activity (GO:1904668) [RO:0002213 relation] RO:0002213  ubiquitin protein ligase activity
negative regulation of ubiquitin protein ligase activity (GO:1904667) [RO:0002212 relation] RO:0002212  ubiquitin protein ligase activity
ubiquitin-ubiquitin ligase activity (GO:0034450) [is_a relation] is_a  ubiquitin protein ligase activity