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Term Information

Accession
GO:0052799
Name
coenzyme F420-dependent bicyclic nitroimidazole catabolic process
Ontology
biological_process
Synonyms
coenzyme F420-dependent nitroimidazole breakdown, coenzyme F420-dependent nitroimidazole catabolism, coenzyme F420-dependent nitroimidazole reduction, coenzyme F420-dependent nitroreductase activity
Alternate IDs
None
Definition
The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates. Source: PMID:19039139, GOC:mengo_curators, PMID:16387854
Comment
None
History
See term history for GO:0052799 at QuickGO
Subset
None
Feedback
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Graph of GO:0052799

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Parents of coenzyme F420-dependent bicyclic nitroimidazole catabolic process (GO:0052799)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
coenzyme F420-dependent bicyclic nitroimidazole catabolic process [is_a relation] is_a  bicyclic nitroimidazole catabolic process (GO:0052800)
Children of coenzyme F420-dependent bicyclic nitroimidazole catabolic process (GO:0052799)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process (GO:1900289) [RO:0002212 relation] RO:0002212  coenzyme F420-dependent bicyclic nitroimidazole catabolic process
regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process (GO:1900288) [RO:0002211 relation] RO:0002211  coenzyme F420-dependent bicyclic nitroimidazole catabolic process
positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process (GO:1900290) [RO:0002213 relation] RO:0002213  coenzyme F420-dependent bicyclic nitroimidazole catabolic process
None.