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Term Information

Accession
GO:0046849
Name
bone remodeling
Ontology
biological_process
Synonyms
bone remodelling
Alternate IDs
None
Definition
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. Source: GOC:curators
Comment
None
History
See term history for GO:0046849 at QuickGO
Subset
None
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Graph of GO:0046849

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Parents of bone remodeling (GO:0046849)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
bone remodeling [is_a relation] is_a  tissue remodeling (GO:0048771)
Children of bone remodeling (GO:0046849)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ossification involved in bone remodeling (GO:0043932) [BFO:0000050 relation] BFO:0000050  bone remodeling
bone resorption (GO:0045453) [BFO:0000050 relation] BFO:0000050  bone remodeling
negative regulation of bone remodeling (GO:0046851) [RO:0002212 relation] RO:0002212  bone remodeling
regulation of bone remodeling (GO:0046850) [RO:0002211 relation] RO:0002211  bone remodeling
positive regulation of bone remodeling (GO:0046852) [RO:0002213 relation] RO:0002213  bone remodeling
Wikipedia
Bone_remodeling