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Term Information

Accession
GO:0046820
Name
4-amino-4-deoxychorismate synthase activity
Ontology
molecular_function
Synonyms
ADC synthase activity, PabB activity, aminodeoxychorismate synthase activity, chorismate:L-glutamine amido-ligase activity, p-aminobenzoate synthetase, para-aminobenzoic acid (PABA) synthase, para-aminobenzoic acid synthase activity
Alternate IDs
None
Definition
Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. Source: EC:2.6.1.85, RHEA:11672
Comment
Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
History
See term history for GO:0046820 at QuickGO
Subset
None
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Parents of 4-amino-4-deoxychorismate synthase activity (GO:0046820)
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4-amino-4-deoxychorismate synthase activity [is_a relation] is_a  transaminase activity (GO:0008483)

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EC
2.6.1.85
KEGG_REACTION
R01716
MetaCyc
PABASYN-RXN
RHEA
11672