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cytosolic pyruvate dehydrogenase complex

Term Information

Accession
GO:0045250
Name
cytosolic pyruvate dehydrogenase complex
Ontology
cellular_component
Synonyms
pyruvate dehydrogenase complex (lipoamide)
Alternate IDs
None
Definition
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. Source: ISBN:0471331309, GOC:mtg_sensu, ISBN:0716720094
Comment
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
History
See term history for GO:0045250 at QuickGO
Subset
None
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Graph of GO:0045250

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Parents of cytosolic pyruvate dehydrogenase complex (GO:0045250)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cytosolic pyruvate dehydrogenase complex [is_a relation] is_a  pyruvate dehydrogenase complex (GO:0045254)
cytosolic pyruvate dehydrogenase complex [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)

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