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Term Information

Accession
GO:0045190
Name
isotype switching
Ontology
biological_process
Synonyms
class switch recombination, class switching, isotype switch recombination
Alternate IDs
None
Definition
The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. Source: ISBN:0781735149
Comment
Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
History
See term history for GO:0045190 at QuickGO
Subset
None
Feedback
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Graph of GO:0045190

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Parents of isotype switching (GO:0045190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
isotype switching [is_a relation] is_a  somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)
isotype switching [is_a relation] is_a  B cell activation involved in immune response (GO:0002312)
Children of isotype switching (GO:0045190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
isotype switching to IgA isotypes (GO:0048290) [is_a relation] is_a  isotype switching
regulation of isotype switching (GO:0045191) [RO:0002211 relation] RO:0002211  isotype switching
negative regulation of isotype switching (GO:0045829) [RO:0002212 relation] RO:0002212  isotype switching
isotype switching to IgD isotypes (GO:0048292) [is_a relation] is_a  isotype switching
isotype switching to IgE isotypes (GO:0048289) [is_a relation] is_a  isotype switching
isotype switching to IgG isotypes (GO:0048291) [is_a relation] is_a  isotype switching
positive regulation of isotype switching (GO:0045830) [RO:0002213 relation] RO:0002213  isotype switching