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Term Information

Accession
GO:0045122
Name
aflatoxin biosynthetic process
Ontology
biological_process
Synonyms
aflatoxin anabolism, aflatoxin biosynthesis, aflatoxin formation, aflatoxin synthesis
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. Source: ISBN:0716731363, ISBN:0815316194, PMID:15006741
Comment
None
History
See term history for GO:0045122 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0045122

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Parents of aflatoxin biosynthetic process (GO:0045122)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  versicolorin B desaturase activity (GO:0140398)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  norsolorinate anthrone synthase activity (GO:0102973)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  sterigmatocystin 7-O-methyltransferase activity (GO:0047146)
aflatoxin biosynthetic process [is_a relation] is_a  aflatoxin metabolic process (GO:0046222)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  norsolorinic acid ketoreductase activity (GO:0140393)
aflatoxin biosynthetic process [is_a relation] is_a  mycotoxin biosynthetic process (GO:0043386)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  averantin hydroxylase activity (GO:0140395)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  demethylsterigmatocystin 6-O-methyltransferase activity (GO:0047145)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  5'-hydroxyaverantin dehydrogenase activity (GO:0140396)
aflatoxin biosynthetic process [is_a relation] is_a  acetate metabolic process (GO:0006083)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  versiconal hemiacetal acetate esterase activity (GO:0140397)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  versicolorin B synthase activity (GO:0046572)
aflatoxin biosynthetic process [BFO:0000051 relation] BFO:0000051  versicolorin reductase activity (GO:0042469)
aflatoxin biosynthetic process [is_a relation] is_a  organic heteropentacyclic compound biosynthetic process (GO:1901378)
Children of aflatoxin biosynthetic process (GO:0045122)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
aflatoxin B synthase activity (GO:0140399) [BFO:0000050 relation] BFO:0000050  aflatoxin biosynthetic process
regulation of aflatoxin biosynthetic process (GO:1900177) [RO:0002211 relation] RO:0002211  aflatoxin biosynthetic process
averantin hydroxylase activity (GO:0140395) [BFO:0000050 relation] BFO:0000050  aflatoxin biosynthetic process
negative regulation of aflatoxin biosynthetic process (GO:1900178) [RO:0002212 relation] RO:0002212  aflatoxin biosynthetic process
positive regulation of aflatoxin biosynthetic process (GO:1900179) [RO:0002213 relation] RO:0002213  aflatoxin biosynthetic process
None.