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Term Information

Accession
GO:0044613
Name
nuclear pore central transport channel
Ontology
cellular_component
Synonyms
nuclear pore central channel, nuclear pore central plug, nuclear pore transport channel, karyopherin docking complex
Alternate IDs
None
Definition
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153. Source: PMID:18046406, GOC:dgf, PMID:19524430, PMID:20947011, PMID:22419078
Comment
None
History
See term history for GO:0044613 at QuickGO
Subset
None
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Parents of nuclear pore central transport channel (GO:0044613)
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nuclear pore central transport channel [is_a relation] is_a  protein-containing complex (GO:0032991)
nuclear pore central transport channel [BFO:0000050 relation] BFO:0000050  nuclear pore (GO:0005643)

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