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Term Information

Accession
GO:0043687
Name
post-translational protein modification
Ontology
biological_process
Synonyms
PTM, post-translational amino acid modification, post-translational modification, posttranslational amino acid modification, posttranslational modification, posttranslational protein modification
Alternate IDs
None
Definition
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. Source: GOC:jsg
Comment
This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term.
History
See term history for GO:0043687 at QuickGO
Subset
None
Feedback
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Graph of GO:0043687

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Parents of post-translational protein modification (GO:0043687)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
post-translational protein modification [is_a relation] is_a  cellular protein modification process (GO:0006464)
Children of post-translational protein modification (GO:0043687)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CAAX-box protein modification (GO:0071587) [is_a relation] is_a  post-translational protein modification
post-translational protein acetylation (GO:0034421) [is_a relation] is_a  post-translational protein modification
C-terminal protein amino acid modification (GO:0018410) [is_a relation] is_a  post-translational protein modification
regulation of post-translational protein modification (GO:1901873) [RO:0002211 relation] RO:0002211  post-translational protein modification
positive regulation of post-translational protein modification (GO:1901875) [RO:0002213 relation] RO:0002213  post-translational protein modification
negative regulation of post-translational protein modification (GO:1901874) [RO:0002212 relation] RO:0002212  post-translational protein modification
N-terminal protein amino acid propionylation (GO:0061606) [is_a relation] is_a  post-translational protein modification