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Term Information

Accession
GO:0042276
Name
error-prone translesion synthesis
Ontology
biological_process
Synonyms
mutagenic PRR, error-prone postreplication DNA repair, mutagenic postreplication DNA repair
Alternate IDs
None
Definition
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. Source: GOC:jl, GOC:elh, PMID:11485998
Comment
None
History
See term history for GO:0042276 at QuickGO
Subset
None
Feedback
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Graph of GO:0042276

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Parents of error-prone translesion synthesis (GO:0042276)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
error-prone translesion synthesis [is_a relation] is_a  translesion synthesis (GO:0019985)
Children of error-prone translesion synthesis (GO:0042276)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of error-prone translesion synthesis (GO:1904332) [RO:0002212 relation] RO:0002212  error-prone translesion synthesis
positive regulation of error-prone translesion synthesis (GO:1904333) [RO:0002213 relation] RO:0002213  error-prone translesion synthesis
regulation of error-prone translesion synthesis (GO:1904331) [RO:0002211 relation] RO:0002211  error-prone translesion synthesis
None.