Planteome: Term Details for "PKR-mediated signaling" (GO:0039585)

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Term Information

Accession: GO:0039585
Name: PKR-mediated signaling
Ontology: biological_process
Synonyms: EIF2AK2 signal transduction, EIF2AK2/PRK signaling, PKR signal transduction, PKR signaling pathway, signaling through PKR
Alternate IDs: None
Definition: A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation. Source: PMID:21204021, PMID:9843495, PMID:22102852, PMID:27629041, VZ:1576
Comment: None
History: See term history for GO:0039585 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to PKR-mediated signaling.; Link to all direct and indirect annotations to PKR-mediated signaling.; Link to all direct and indirect annotations download (limited to first 10,000) for PKR-mediated signaling.
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