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Term Information

Accession
GO:0039585
Name
PKR-mediated signaling
Ontology
biological_process
Synonyms
EIF2AK3 signal transduction, EIF2AK3/PERK signaling, PKR signal transduction, PKR signaling pathway, signaling through PKR
Alternate IDs
None
Definition
A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation. Source: PMID:21204021, PMID:9843495, PMID:22102852, PMID:27629041, VZ:1576
Comment
None
History
See term history for GO:0039585 at QuickGO
Subset
None
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Graph of GO:0039585

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Parents of PKR-mediated signaling (GO:0039585)
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PKR-mediated signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
PKR-mediated signaling [is_a relation] is_a  integrated stress response signaling (GO:0140467)

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None.