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Term Information

Accession
GO:0038128
Name
ERBB2 signaling pathway
Ontology
biological_process
Synonyms
ERBB2 signalling pathway, HER2 signaling pathway, NEU signaling, receptor tyrosine-protein kinase erbB-2 signaling pathway
Alternate IDs
None
Definition
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. Source: Reactome:R-HSA-1227986, PMID:16460914, GOC:jc
Comment
None
History
See term history for GO:0038128 at QuickGO
Subset
None
Feedback
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Graph of GO:0038128

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Parents of ERBB2 signaling pathway (GO:0038128)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERBB2 signaling pathway [is_a relation] is_a  ERBB signaling pathway (GO:0038127)
Children of ERBB2 signaling pathway (GO:0038128)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERBB2-EGFR signaling pathway (GO:0038134) [is_a relation] is_a  ERBB2 signaling pathway
ERBB2-ERBB3 signaling pathway (GO:0038133) [is_a relation] is_a  ERBB2 signaling pathway
ERBB2-ERBB4 signaling pathway (GO:0038135) [is_a relation] is_a  ERBB2 signaling pathway
None.