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Term Information

Accession
GO:0038061
Name
NIK/NF-kappaB signaling
Ontology
biological_process
Synonyms
NIK/NF-kappaB signal transduction, NIK/NF-kappaB cascade, p52-dependent NF-kappaB signaling, non-canonical NF-KB signaling, noncanonical NF-kappaB signaling, noncanonical nuclear factor kappaB (NF-kappaB) pathway
Alternate IDs
None
Definition
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). Source: GOC:signaling, PMID:15140882, GOC:vs, PMID:11239468, GOC:bf, GOC:mg2
Comment
None
History
See term history for GO:0038061 at QuickGO
Subset
None
Feedback
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Graph of GO:0038061

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Parents of NIK/NF-kappaB signaling (GO:0038061)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
NIK/NF-kappaB signaling [BFO:0000051 relation] BFO:0000051  positive regulation of NF-kappaB transcription factor activity (GO:0051092)
NIK/NF-kappaB signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of NIK/NF-kappaB signaling (GO:0038061)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of NIK/NF-kappaB signaling (GO:1901222) [RO:0002211 relation] RO:0002211  NIK/NF-kappaB signaling
negative regulation of NIK/NF-kappaB signaling (GO:1901223) [RO:0002212 relation] RO:0002212  NIK/NF-kappaB signaling
positive regulation of NIK/NF-kappaB signaling (GO:1901224) [RO:0002213 relation] RO:0002213  NIK/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity (GO:0007250) [BFO:0000050 relation] BFO:0000050  NIK/NF-kappaB signaling
NF-kappaB-inducing kinase activity (GO:0004704) [BFO:0000050 relation] BFO:0000050  NIK/NF-kappaB signaling
None.