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Term Information

Accession
GO:0036500
Name
ATF6-mediated unfolded protein response
Ontology
biological_process
Synonyms
ATF6 branch of UPR, UPR signaling by ATF6 stress sensor, activating transcription factor 6 signaling in unfolded protein response, endoplasmic reticulum unfolded protein response; ATF6 signaling, ATF6 signaling in response to endoplasmic reticulum stress, ATF6-alpha UPR branch, ATF6-beta UPR branch, ATF6 signal transduction pathway
Alternate IDs
None
Definition
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. Source: GOC:PARL, PMID:22013210, GOC:bf
Comment
None
History
See term history for GO:0036500 at QuickGO
Subset
None
Feedback
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Graph of GO:0036500

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Parents of ATF6-mediated unfolded protein response (GO:0036500)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ATF6-mediated unfolded protein response [is_a relation] is_a  endoplasmic reticulum unfolded protein response (GO:0030968)
ATF6-mediated unfolded protein response [is_a relation] is_a  ER-nucleus signaling pathway (GO:0006984)
Children of ATF6-mediated unfolded protein response (GO:0036500)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of ATF6-mediated unfolded protein response (GO:1903892) [RO:0002212 relation] RO:0002212  ATF6-mediated unfolded protein response
regulation of ATF6-mediated unfolded protein response (GO:1903891) [RO:0002211 relation] RO:0002211  ATF6-mediated unfolded protein response
positive regulation of ATF6-mediated unfolded protein response (GO:1903893) [RO:0002213 relation] RO:0002213  ATF6-mediated unfolded protein response
None.