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Term Information

Accession
GO:0036499
Name
PERK-mediated unfolded protein response
Ontology
biological_process
Synonyms
PERK branch of UPR, PKR-like ER kinase signal transduction, UPR signaling by PERK stress sensor, endoplasmic reticulum unfolded protein response; PERK signaling, EIF2AK3-mediated unfolded protein response, PERK signaling in response to endoplasmic reticulum stress, eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response, PERK signal transduction pathway
Alternate IDs
None
Definition
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. Source: GOC:PARL, PMID:22013210, GOC:bf, PMID:27629041
Comment
None
History
See term history for GO:0036499 at QuickGO
Subset
None
Feedback
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Graph of GO:0036499

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Parents of PERK-mediated unfolded protein response (GO:0036499)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
PERK-mediated unfolded protein response [is_a relation] is_a  ER-nucleus signaling pathway (GO:0006984)
PERK-mediated unfolded protein response [is_a relation] is_a  integrated stress response signaling (GO:0140467)
PERK-mediated unfolded protein response [is_a relation] is_a  endoplasmic reticulum unfolded protein response (GO:0030968)
Children of PERK-mediated unfolded protein response (GO:0036499)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of PERK-mediated unfolded protein response (GO:1903899) [RO:0002213 relation] RO:0002213  PERK-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response (GO:1903898) [RO:0002212 relation] RO:0002212  PERK-mediated unfolded protein response
regulation of PERK-mediated unfolded protein response (GO:1903897) [RO:0002211 relation] RO:0002211  PERK-mediated unfolded protein response
None.