Planteome: Term Details for "PERK-mediated unfolded protein response" (GO:0036499)

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Term Information

Accession: GO:0036499
Name: PERK-mediated unfolded protein response
Ontology: biological_process
Synonyms: PERK branch of UPR, PKR-like ER kinase signal transduction, UPR signaling by PERK stress sensor, endoplasmic reticulum unfolded protein response; PERK signaling, EIF2AK3-mediated unfolded protein response, PERK signaling in response to endoplasmic reticulum stress, eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response, PERK signal transduction pathway
Alternate IDs: None
Definition: The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. Source: GOC:PARL, PMID:22013210, GOC:bf, PMID:27629041
Comment: None
History: See term history for GO:0036499 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to PERK-mediated unfolded protein response.; Link to all direct and indirect annotations to PERK-mediated unfolded protein response.; Link to all direct and indirect annotations download (limited to first 10,000) for PERK-mediated unfolded protein response.
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BFO:0000001 entity
BFO:0000003 occurrent
GO:0050896 response to stimulus
GO:0008150 biological_process
GO:0051716 cellular response to stimulus
GO:0042221 response to chemical
GO:0065007 biological regulation
GO:0070887 cellular response to chemical stimulus
BFO:0000015 process
GO:0010033 response to organic substance
GO:0006950 response to stress
GO:0009987 cellular process
GO:0071310 cellular response to organic substance
GO:0033554 cellular response to stress
GO:0050789 regulation of biological process
GO:0035966 response to topologically incorrect protein
GO:0007154 cell communication
GO:0035967 cellular response to topologically incorrect protein
GO:0050794 regulation of cellular process
GO:0006986 response to unfolded protein
GO:0023052 signaling
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0007165 signal transduction
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0006984 ER-nucleus signaling pathway
GO:0140467 integrated stress response signaling
GO:0036499 PERK-mediated unfolded protein response
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903899 positive regulation of PERK-mediated unfolded protein response
GO:1903897 regulation of PERK-mediated unfolded protein response

Parents of PERK-mediated unfolded protein response (GO:0036499)

subject	relation	object
PERK-mediated unfolded protein response	is_a	endoplasmic reticulum unfolded protein response (GO:0030968)
PERK-mediated unfolded protein response	is_a	integrated stress response signaling (GO:0140467)
PERK-mediated unfolded protein response	is_a	ER-nucleus signaling pathway (GO:0006984)

Children of PERK-mediated unfolded protein response (GO:0036499)

subject	relation	object
positive regulation of PERK-mediated unfolded protein response (GO:1903899)	RO:0002213	PERK-mediated unfolded protein response
regulation of PERK-mediated unfolded protein response (GO:1903897)	RO:0002211	PERK-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response (GO:1903898)	RO:0002212	PERK-mediated unfolded protein response