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Term Information

Accession
GO:0036498
Name
IRE1-mediated unfolded protein response
Ontology
biological_process
Synonyms
IRE1 branch of UPR, UPR signaling by IRE1 stress sensor, endoplasmic reticulum unfolded protein response; IRE1 signaling, ERN1-mediated unfolded protein response, IRE1 signaling in response to endoplasmic reticulum stress, inositol-requiring enzyme 1-mediated unfolded protein response, inositol-requiring transmembrane kinase/endonuclease signal transduction, IRE1alpha unfolded protein response, IRE1p unfolded protein response, IRE1 signal transduction pathway
Alternate IDs
None
Definition
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. Source: GOC:PARL, PMID:22013210, GOC:bf
Comment
Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
History
See term history for GO:0036498 at QuickGO
Subset
None
Feedback
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Graph of GO:0036498

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Parents of IRE1-mediated unfolded protein response (GO:0036498)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IRE1-mediated unfolded protein response [is_a relation] is_a  endoplasmic reticulum unfolded protein response (GO:0030968)
Children of IRE1-mediated unfolded protein response (GO:0036498)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of IRE1-mediated unfolded protein response (GO:1903895) [RO:0002212 relation] RO:0002212  IRE1-mediated unfolded protein response
regulation of IRE1-mediated unfolded protein response (GO:1903894) [RO:0002211 relation] RO:0002211  IRE1-mediated unfolded protein response
positive regulation of IRE1-mediated unfolded protein response (GO:1903896) [RO:0002213 relation] RO:0002213  IRE1-mediated unfolded protein response
None.