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Term Information

Accession
GO:0036316
Name
SREBP-SCAP complex retention in endoplasmic reticulum
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER. Source: GOC:bf, PMID:16525117
Comment
Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937.
History
See term history for GO:0036316 at QuickGO
Subset
None
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Graph of GO:0036316

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Parents of SREBP-SCAP complex retention in endoplasmic reticulum (GO:0036316)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
SREBP-SCAP complex retention in endoplasmic reticulum [BFO:0000050 relation] BFO:0000050  cellular response to sterol (GO:0036315)
SREBP-SCAP complex retention in endoplasmic reticulum [is_a relation] is_a  maintenance of protein localization in endoplasmic reticulum (GO:0035437)
SREBP-SCAP complex retention in endoplasmic reticulum [is_a relation] is_a  negative regulation of SREBP signaling pathway (GO:2000639)

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