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Term Information

Accession
GO:0036166
Name
phenotypic switching
Ontology
biological_process
Synonyms
phenotypic dimorphism
Alternate IDs
None
Definition
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues. Source: PMID:8456504, GOC:bf, GOC:di, PMID:22406749, Wikipedia:Phenotypic_switching, PMID:12443899
Comment
Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
History
See term history for GO:0036166 at QuickGO
Subset
None
Feedback
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Graph of GO:0036166

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Parents of phenotypic switching (GO:0036166)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
phenotypic switching [is_a relation] is_a  cellular process (GO:0009987)
Children of phenotypic switching (GO:0036166)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
establishment or maintenance of cell type involved in phenotypic switching (GO:0044663) [BFO:0000050 relation] BFO:0000050  phenotypic switching
positive regulation of phenotypic switching (GO:1900241) [RO:0002213 relation] RO:0002213  phenotypic switching
negative regulation of phenotypic switching (GO:1900240) [RO:0002212 relation] RO:0002212  phenotypic switching
regulation of cell morphogenesis involved in phenotypic switching (GO:1900447) [BFO:0000050 relation] BFO:0000050  phenotypic switching
phenotypic switching in response to host (GO:0036167) [is_a relation] is_a  phenotypic switching
regulation of phenotypic switching (GO:1900239) [RO:0002211 relation] RO:0002211  phenotypic switching
reversible differentiation (GO:0090677) [is_a relation] is_a  phenotypic switching
None.