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Term Information

Accession
GO:0035591
Name
signaling adaptor activity
Ontology
molecular_function
Synonyms
signalling adaptor activity, signaling scaffold activity
Alternate IDs
None
Definition
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. Source: GOC:bf, PMID:19104498
Comment
A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498).
History
See term history for GO:0035591 at QuickGO
Subset
None
Feedback
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Graph of GO:0035591

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Parents of signaling adaptor activity (GO:0035591)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
signaling adaptor activity [is_a relation] is_a  protein-macromolecule adaptor activity (GO:0030674)
Children of signaling adaptor activity (GO:0035591)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
JAK pathway signal transduction adaptor activity (GO:0008269) [is_a relation] is_a  signaling adaptor activity
MAP-kinase scaffold activity (GO:0005078) [is_a relation] is_a  signaling adaptor activity
signaling receptor complex adaptor activity (GO:0030159) [is_a relation] is_a  signaling adaptor activity
None.