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Term Information

Accession
GO:0035333
Name
Notch receptor processing, ligand-dependent
Ontology
biological_process
Synonyms
Notch S2 cleavage, Notch S3 cleavage
Alternate IDs
None
Definition
The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). Source: PMID:12651094, GOC:bf
Comment
None
History
See term history for GO:0035333 at QuickGO
Subset
None
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Graph of GO:0035333

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Parents of Notch receptor processing, ligand-dependent (GO:0035333)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Notch receptor processing, ligand-dependent [BFO:0000050 relation] BFO:0000050  Notch signaling pathway (GO:0007219)
Notch receptor processing, ligand-dependent [is_a relation] is_a  membrane protein intracellular domain proteolysis (GO:0031293)
Notch receptor processing, ligand-dependent [BFO:0000050 relation] BFO:0000050  Notch receptor processing (GO:0007220)

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None.