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Term Information

Accession
GO:0035329
Name
hippo signaling
Ontology
biological_process
Synonyms
hippo signal transduction, hippo signaling pathway, hippo signaling cascade, hippo signalling cascade, SWH pathway, Salvador-Warts-Hippo signaling pathway
Alternate IDs
None
Definition
The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. Source: PMID:17318211, PMID:18328423
Comment
None
History
See term history for GO:0035329 at QuickGO
Subset
None
Feedback
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Graph of GO:0035329

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Parents of hippo signaling (GO:0035329)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
hippo signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of hippo signaling (GO:0035329)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of hippo signaling (GO:0035330) [RO:0002211 relation] RO:0002211  hippo signaling
negative regulation of hippo signaling (GO:0035331) [RO:0002212 relation] RO:0002212  hippo signaling
positive regulation of hippo signaling (GO:0035332) [RO:0002213 relation] RO:0002213  hippo signaling
None.