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Term Information

Accession
GO:0035195
Name
gene silencing by miRNA
Ontology
biological_process
Synonyms
gene silencing by microRNA, miRNA-mediated gene silencing, microRNA-mediated gene silencing
Alternate IDs
None
Definition
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. Source: PMID:28379604, PMID:23985560, GOC:bc, PMID:15066283, PMID:14744438, GOC:aruk, PMID:15066275, GOC:rl, PMID:23209154
Comment
None
History
See term history for GO:0035195 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0035195

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Parents of gene silencing by miRNA (GO:0035195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
gene silencing by miRNA [is_a relation] is_a  post-transcriptional gene silencing by RNA (GO:0035194)
Children of gene silencing by miRNA (GO:0035195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
deadenylation involved in gene silencing by miRNA (GO:0098806) [BFO:0000050 relation] BFO:0000050  gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA (GO:0035280) [BFO:0000050 relation] BFO:0000050  gene silencing by miRNA
positive regulation of gene silencing by miRNA (GO:2000637) [RO:0002213 relation] RO:0002213  gene silencing by miRNA
miRNA mediated inhibition of translation (GO:0035278) [BFO:0000050 relation] BFO:0000050  gene silencing by miRNA
mRNA cleavage involved in gene silencing by miRNA (GO:0035279) [BFO:0000050 relation] BFO:0000050  gene silencing by miRNA
pre-miRNA export from nucleus (GO:0035281) [BFO:0000050 relation] BFO:0000050  gene silencing by miRNA
negative regulation of gene silencing by miRNA (GO:0060965) [RO:0002212 relation] RO:0002212  gene silencing by miRNA
production of miRNAs involved in gene silencing by miRNA (GO:0035196) [BFO:0000050 relation] BFO:0000050  gene silencing by miRNA
regulation of gene silencing by miRNA (GO:0060964) [RO:0002211 relation] RO:0002211  gene silencing by miRNA
None.