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Term Information

Accession
GO:0032044
Name
DSIF complex
Ontology
cellular_component
Synonyms
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex, DRB sensitivity inducing factor complex, Spt4-Spt5 complex, Spt5-Spt4 complex
Alternate IDs
None
Definition
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. Source: PMID:12676794, PMID:16581788, PMID:19460865, PMID:12242279, PMID:12653964
Comment
None
History
See term history for GO:0032044 at QuickGO
Subset
None
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Graph of GO:0032044

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Parents of DSIF complex (GO:0032044)
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DSIF complex [is_a relation] is_a  transcription elongation factor complex (GO:0008023)

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